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KMID : 0368420130560040198
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Journal of Plant Biology
2013 Volume.56 No. 4 p.198 ~ p.207
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RNA deadenylation and decay in plants
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Abbasi Nazia
Park Youn-Il
Choi Sang-Bong
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Abstract
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In eukaryotic cells, RNA levels are tightly regulated in a spatio-temporal manner to maintain the protein levels necessary for cell growth, differentiation and division. To cope with developmental and rapid environmental changes, RNAs that are no longer required by the cell undergo degradation via the mRNA decay process. A number of players involved in RNA degradation pathways have been identified for the last two decades. A wealth of information about the process of mRNA deadenylation and decay in yeast and other model organisms is currently available; however, very limited information is available in plants, including Arabidopsis. Nevertheless, the efforts of various plant research groups are continuously extending our understanding of this complicated process. Here, we summarize our current knowledge of RNA decay in yeast and compare this information with the progress from Arabidopsis. This review will especially focus on the structure and function of the deadenylation complex, 5′ to 3′ exoribonuclease (XRN)-mediated decay pathways and the exosome-mediated 3′ to 5′ decay pathway in plants.
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KEYWORD
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Deadenylase complex, Exonuclease, Exosome, mRNA decay, RNA-binding proteins
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